RD is currently untreatable and the underlying cellular mechanisms

However, the activity of the enzyme poly ADP ribose polymerase 1 (PARP1) and excessive generation of poly ADP ribose (PAR) polymers in photoreceptor nuclei have been shown to be causally involved in RD. The activity of PARP1 is to a large extent governed by its functional antagonist, poly ADP glycohydrolase (PARG), which thus also may have a role in RD.

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